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discovered EGCG attenuated the infiltration of neutrophils caused by phorbol ester-type skin tumor promoters in the skin tissue of SENCAR mice, and attributed this phenomenon to the inhibitory effect of EGCG on oxidative events ( Neutrophil elastase (NE), a major serine protease of neutrophils, is stored in the primary granules of neutrophils and released into the surrounding environment with neutrophil stimulation and activation ( 3 Regulatory effects on stroma cells in TME Its commonly known that tumorigenesis is usually accompanied by the formation of the tumor bed as well as the remodeling of the surrounding extracellular matrix (ECM), in which tumor stromal cells play a pivotal role, thus forming a suitable TME for tumor cell survival, so targeting relevant stromal cells is critical to cancer treatment