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The causes of B12 deficiency and the relationship between this deficiency and MTHFR mutations is complex

Vitamin B12 injections deliver methylcobalamin or cyanocobalamin directly into muscle tissue, bypassing the digestive tract

However, the largest Phase IIb trial involving 536 subjects failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading Metabolic Pharmaceuticals to terminate development in 2007

This is the long-term strategy, with less frequent injectionsmaybe weekly, monthly, or even every few months

not intended as therapeutic claims

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