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12,20 PROM scores from early in the disease course are also predictors of long-term MS outcomes, such as use of a unilateral support (EDSS 6.0) and transition to a progressive phenotype

For the anti and syn conformers of the keto-enol state, an input geometry for the higher energy anti -conformation was manually generated by rotating the orientation of the OH bond of the syn conformer by 180

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The native peptide has limited blood-brain barrier penetration, which is part of why some recent research has focused on DSIP fusion peptides combined with cell-penetrating sequences (like Tat) to improve CNS delivery

Together, these peptides provide a valuable research model for exploring the coordinated biological processes involved in tissue maintenance and regenerative biology