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HK2 is the initial key enzyme in glycolysis, responsible for converting glucose into the metabolic intermediate G-6-P

Increased level of CD44 enables self-renewal and is also associated with metastasis and poor prognosis

Additional symptoms can include unusually pale skin (pallor), abdominal pain, diarrhea, headache, fever, and an increased sensitivity to light (photophobia) or to sound (phonophobia)