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10.1007/s10620-019-05777-2 21

[94] Clinical Diagnosis: Repeated sun exposure promotes the development of recurrent blisters and erosions, with secondary infections that may result in severe scarring, sclerodermatous change, and deformities of the hand.[95] Sclerodactyly, osteolysis and shortening of the phalanges, and progressive joint deformities can occur as well

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U., Foley M., Schenone M., Li X., et al

Coordinated interactions between stress response systems, occurring at multiple levels including the brain, pituitary gland, adrenal gland, and peripheral tissues, are required for the maintenance of homeostatic plateau

For example, a study of MTHFR polymorphism genotypes in colorectal cancer patients reported that the frequency of methylated Bcl-2 promoter was significantly higher in individuals with CC genotype than that of those with CT and TT genotypes, and a significant difference of C and T alleles distribution were observed between patients with methylated and unmethylated Bcl-2 promoter 35