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10.1074/jbc.REV119.006217 98 HeX.-f.LiuD.-x.ZhangQ.LiangF.-y.DaiG.-y.ZengJ.-s.et al (2017)

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Although p53 induced apoptosis via PUMA and NOXA and cell senescence via p21 play critical roles in preventing cells from malignant transformation, these two mechanisms are dispensable for p53-mediated suppression of spontaneous tumour development
Consistent use over several weeks or even months is often needed to see significant changes

Viral glycoproteins have been identified as preferred target sites for antiviral drugs in the past due to their importance in viral attachment and entry [70]

Trypsin without the proline restriction enzyme option was used, with two allowed miscleavages
