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Chest 164(3):606613 Rademacher J, Konwert S, Fuge J et al (2020) Anti-IL5 and anti-IL5Ra therapy for clinically significant bronchiectasis with eosinophilic endotype: a case series

However, the trial outcome was encouraging, with good patient tolerability [95]

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In the OIR model where the VEGF receptor tyrosine kinase inhibitor KRN633 was used to block VEGF signaling to establish capillary-free zones in the central and peripheral retinas of neonatal mice, revascularization was found to occur following the cessation of treatment, with the re-formed fibronectin (provisional matrix) serving as a scaffold for revascularization 131

Together, our findings illustrate the prominent influence of the tissue immunomicrotope (Bogdan et al., 2024) on the transcriptome and function of eosinophils and highlight a novel immunoregulatory activity of these innate immune cells

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