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In the presence of ATP and coenzyme A, the enzyme acyl-CoA synthetase (thiokinase) catalyzes the conversion of a fatty acid (or FFA) to an active fatty acid or acyl-CoA, which uses one high-energy phosphate with the formation of AMP and PP i (Figure 221)

However, neuroinflammation and the consequent dysregulation of neural homeostasis and plasticity is likely to be a more common mechanistic principle, occurring even after mild COVID-19 disease [141]

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In addition to humans, TMAO has also been shown to worsen impaired glucose tolerance in animals

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