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Tesofensine lowers body weight mainly by reducing appetite, increasing satiety, and enhancing energy expenditure, making it a promising candidate for the pharmacological treatment of obesity 1-4

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The current injectable GLP-1 therapies, despite their efficacy, reach only a small fraction of the eligible population due to cost, injection barriers, manufacturing constraints, and supply limitations

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Research shows that CML cells with the BCR-ABL-T315I mutation treated with AKI603 display features typical of senescent cells, such as increased SA--Gal activity, altered morphology, elevated levels of p53, p21, p27, and p16, as well as SASP secretion [79]

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