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Description
The activation of the Na + /H + exchanger (NHE), as an attempt to correct acidosis, leads to an accumulation of intracellular Na + , which in turn inhibits Ca 2+ extrusion through the Na + /Ca 2+ exchanger (NCX), thereby contributing to calcium overload [163]
Clinics (Sao Paulo) 2012;67:12091214
This insufficient targeting leads to low NADs concentrations at the disease site and unintended gene silencing or activation, potentially causing safety issues by requiring higher doses
The BBOX1 gene is located on chromosome 11p14.2 and is composed of 11 exons that generate five alternatively spliced mRNAs, all of which encode the same 387 amino acid protein
The released ROS activate the ion channel TRPM2 in macrophages, promoting calcium influx, thereby eliciting an immune response
Kvestad, I
