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reported that LKB1 mutation in KRAS mutant lung adenocarcinoma confers a glutamate enriched phenotype in TME, and this feature was associated with CD8 + T cell activation against PD-1, whereas treatment with the glutaminase inhibitor CB-839 inhibited CD8 + T cell expansion and activation

Beyond SLC7A11, p53 can indirectly promote lipid peroxidation by activating other downstream targets

described that even with a high-fat diet, exercise could reduce inflammatory infiltration and protect gut morphology and integrity (176)

It has been shown to increase the flow of free fatty acids, the fuel source for mitochondria, resulting in a significant boost in energy production

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Acta 21502163 , 2014