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Emerg Microbes Infect 8(1):282-90 2019 PMC6455179 Attia EF, Pho Y, Nhem S, Sok C, By B, Phann D, Nob H, Thann S, Yin S, Noce R, Kim C, Letchford J, Fassier T, Chan S, West TE

Evidence from both rodent and human studies supports health-related benefits when used as a therapeutic agent

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York, AJ

Thus, the accumulation of lactate has the capacity to inhibit NH3 production by deactivating alpha-ketoglutarate dehydrogenase, which can activate the regulatory enzyme of the glycolytic pathway, phosphofructokinase 1