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In normal subjects, the urinary clearance of TMAO was 219 78 mL/min compared to the urinary urea and creatinine clearances 55 14 and 119 21 mL/min, respectively

The consumption of acetyl-CoA in irreversible metabolic pathways, i.e., lipoic acid and citrate synthesis within the mitochondria followed by biosynthetic processes within the cytosol (Figure 1), drives the process and maintains the mitochondrial content of acetyl-CoA within a safe range

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Upon discharge from the hospital, he was treated with 200mg of carbamazepine TID and 1g of l-carnitine SID