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Unfortunately, currently available mAb imaging probes for the detection of MM are not suitable for use in patients treated with daratumumab, due to overlapping binding epitopes with daratumumab binding site [101] [102]

[163, 165] have reported that off-target toxicity in peripheral organs remained minimal, although they emphasised that excessively high doses or positively charged CQDs may still provoke ROS formation, mitochondrial dysfunction, or the activation of inflammatory pathways [163, 165]

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