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[DOI] [PMC free article] [PubMed] [Google Scholar] 213.Shetty S, Kusminski CM, Scherer PE
In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance, increased glucose levels, obesity, and cardiovascular disease), discussing whether IGF-1 replacement therapy could be a beneficial strategy for these patients
The pivotal primate study was published in Science Translational Medicine in 2011
