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Biologic agents in osteoarthritis: hopes and disappointments
As a tripleagonist peptide, it works on three key hormone pathways (GIP, GLP-1, and glucagon receptors) to help regulate appetite, boost calorie burn, and improve the bodys overall metabolic efficiency
It occurs naturally in human plasma, declining from ~200 ng/mL in young adults to ~80 ng/mL with age
doi: 10.1016/j.immuni.2019.04.011 [DOI] [PMC free article] [PubMed] [Google Scholar] 139
In patients with severe obesity accompanied by complex conditions, this approach should be considered a therapeutic option [136]
Side effects are typically limited to temporary soreness, swelling, or bruising at the injection site, most resolving within 24 to 48 hours
