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doi: 10.4049/jimmunol.1602110 128 ShenYWenZLiYMattesonELHongJGoronzyJJet al

Treatment of psoriasis with 6-aminonicotinamide, which inhibits the 6PGD reaction in the oxPPP, decreased itching and cleared some lesions 133

Of note, five interactors contain a small GTP-binding protein domain (Rab1B, Rab5C, Rab11A, Ran, and EEF1G)

Ferroptosis has been shown to follow a different cell death pathway from apoptosis and thus is attracting attention as a new target for cancer therapy

Figure 1 2 Review methodology To carry out this updated review on the anticancer effects of bromelain, published studies were searched in specialized databases such as PubMed/MedLine, TRIP database, GeenMedical, Scopus, Web of Science and Google Scholar, using the next MeSH terms: Animals, Anticarcinogenic Agents/pharmacology, Antineoplastic Agents/pharmacology, Bromelain/pharmacology, Bromelain/administration and dosage, Bromelain/chemistry, Cell Line, Tumor, Cell Survival/drug effects, Dose-Response Relationship, Drug, Humans, Nanocapsules/administration and dosage, Neoplasms/drug therapy, Neoplasms, Experimental/pathology, Signal Transduction/drug effects, Treatment Outcome