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2.2 In vivo models In the last 30 years numerous animal models for CF have been developed for research purposes

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Although Snitrosylation targets only certain Cys residues, this selectivity can be partially abolished by transnitrosylation, during which a low-molecular-weight nitrosothiol (e.g., GSNO) or a protein nitrosylated at Cys residue or bearing a nitrosylated metal ion (e.g., in the heme) can interact with a protein undergoing Snitrosylation and transfer nitroso group (ON-) to the Cys residue of this protein: PrS + PrSNO PrSNO + PrS , PrS + MeSNO PrSNO + Me

Additional well-designed clinical trials are needed to affirm these findings