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The literature search supports the conclusion that metformin is neuroprotective against DM-induced neuronal cell degeneration in both peripheral and central nervous systems, and this effect is likely mediated via modulation of oxidative stress, inflammation, and cell death pathways.

This dual clinical-pharmacy formulation approach ensures that active ingredients are present at evidence-supported concentrations, with bioavailability considerations built into the sachet delivery format

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Symptomatic treatments such as inhibition of salivation, alleviation of muscle cramps, and relief of spasticity and pain still play an important role in enhancing the quality of life