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284,285,286 Moreover phase I clinical trial has shown that the combination of DSFCu and temozolomide has an acceptable safety profile and increases progression-free survival in patients with glioblastoma 287 (Table 1)

However, these anticancer agents do not selectively kill senescent cells and have only a narrow safe concentration range

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J Gastrointest Oncol 9:208219 Lei Y, Tang L, Chen Q, Wu L, He W, Tu D, Wang S, Chen Y, Liu S, Xie Z, Wei H, Yang S, Tang B (2022) Disulfiram ameliorates nonalcoholic steatohepatitis by modulating the gut microbiota and bile acid metabolism

BAL (dimercaprol) is an intramuscularly administered chelator used to treat acute poisoning caused by mercury, arsenic, lead, and gold