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Long-term safety for broad wellness use is not well established
Steensels S, Depoortere I

Renal oxygenation defects in the spontaneously hypertensive rat: role of AT1 receptors
That said, there are no known risks of taking Vitamin B in combination with blood pressure medication, as long as you are treating a vitamin deficit and not going above the recommended daily dose

MOR activation silences GABAergic VTA neuron firing and reduces evoked and spontaneous TTX-sensitive GABA release (Xiao and Ye, 2008)

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