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Although follicular lumen expansion is a thyroglobulin-independent process (Liang et al, 2018), the initial microlumen formation may be thyroglobulin-dependent, although additional studies in thyroid organoids lacking Nrf2 are necessary to confirm this hypothesis

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Abad V, Meyers JL, Weise M, Gafni RI, Barnes KM, Nilsson O, et al

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Subsequently, other miRNAs have been identified to control Nrf2 levels in the cell

This enzyme promotes the conversion of two superoxide radicals to hydrogen peroxide and molecular oxygen, reducing the toxicity of ROS because it converts a highly reactive species to a less harmful one [13]