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"Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product"

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Besides its function serving as a cofactor, recent findings suggest that the central Co atom of B 12 undergoes several reduction/oxidation steps ranging from 1+ to 3+, both in the cytosol and in mitochondria

That means that the molecules are designed to combine with body fluids and absorb through the mucous membranes of the body (mouth and digestive tract), instead of relying on absorption through the gut (which is no good)

Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat -cells by a protein kinase Amediated mechanism

In Listeria monocytogenes hierarchal regulation mediated by the B 12 riboswitch has been observed [145]