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Nonclinical CNS safety assessments of chronic nose-to-brain drug delivery should therefore incorporate evaluations of cognitive and olfactory functions in laboratory animals, as the olfactory bulb and prefrontal cortex, which play key roles in olfaction and cognition, respectively, are anatomically proximal to the intranasal administration site

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And 5-FU and capecitabine are still powerful tools against many cancers

5), suggesting that majority of cysteine is utilized for protein synthesis

Holverda, S., Rutgers, M
