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Translational percentages (concordance rates) of results exhibit a wide range from 0100% with no predictable factors for translational success or failure in humans (309), and even multiple experiments fail to significantly contribute to improving the reproducibility of animal testing, accounting for 41%72% of the observed total variance (310, 311)

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Furthermore, this analysis found no clear advantages of nutritional interventions, noting that only a limited number of such trials were assessed [145]