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Impaired endothelium-dependent vasodilation in patients with essential hypertension

Methylglyoxal down-regulates the expression of cell cycle associated genes and activates the p53 pathway in human umbilical vein endothelial cells

Although RNA therapy has been significantly beneficial in the treatment of diseases And both pre-clinical And clinical studies have provided promising results, it should be noted that some of them have faced also challenges And failure

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To bypass the pharmacological challenges associated with unspecific blocking of NMDA receptors, we designed a peptidedrug conjugate comprising the NMDA receptor antagonist MK-801 and a GLP-1 peptide analogue

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