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While the formation of this scar is vital to address immediate damage, it may also establish a barrier that impedes axon regrowth (reviewed in (Cooke et al., 2022))

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The sex distribution in the population with Down syndrome was 43% females and 57% males

In plasma, it is released through enzymatic degradation of larger proteins, particularly SPARC (secreted protein acidic and rich in cysteine, also called osteonectin) and collagen

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