glutathione biology definition Glutathione- The Ultimate Antioxidant — Purifi IV The Biological Functions of Glutathione

The negative association between GSH/GSSG, and oxidative protein and DNA damage suggest that decreased glutathione redox capacity in the autism brain may have functional consequence in terms of increased mitochondrial superoxide production and a chronic inflammatory state

Compelling evidence has shown that oncogene-induced replication stress and dNTP exhaustion 30,31

Pastori D, Pani A, Di Rocco A, et al

Fassbender et al., 2012)

In line with the findings in humans, IGFBP-2 serum concentrations were markedly increased in nephrotic animals despite excessive urinary losses due to increased hepatic synthesis, whereas hepatic synthesis of IGFBP-3 was unchanged compared to controls

Another example regards two isoforms of glutathione-S-transferase: M3 (GSTM3) and pi (GSTP1) [269]