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Metabolically, it reduced hyperinsulinemia and improved insulin sensitivity (HOMA-IR), accompanied by enhanced ovarian antioxidant defenses

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The effects of different sex-linked dwarf variations on Chinese native chickens

In another study, pre-treatment of rat pheochromocytoma PC12 cells, often differentiated as a neuronal cell model, with the H 2 S-donor sildenafil (16 M for 30 min) significantly prevented apoptosis and ROS production induced by Hcy (5 mM for 24 h), probably via activation of the atheroprotective paraoxonase-1 (PON-1) enzyme [147,148]

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The primary efficacy endpoint of the larger trial did not reach statistical significance, warranting confirmation in future studies