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Using gene editing tools such as CRISPR/Cas9, researchers can knock out key genes like PHGDH to directly regulate serine synthesis at the genetic level

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Enzymatic treatment included 40U DNase-I, 1000 g/ml Amylase, 500 g/ml Proteinase K and a combination of 40U DNase-I + 4 g/mL amikacin or 40U DNase-I + 30 mM GSH

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