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Methylglyoxal and Stress Increased MG levels is a general response of plant to abiotic stress [23,24,167,180]

This indicated that different bacterial GGTs can adopt different conformations

These genes regulate essential cellular processes, including mitochondrial function, autophagy, lysosomal activity, proteasomal degradation, cellular stress responses, inflammation, and synaptic homeostasis, all of which contribute to the pathogenesis of the disease [24]

It is essential for the production of myelin, a protective layer around nerves that helps transmit signals efficiently in the brain

Figure 5 Series of XICs quantifying N 392 deamidation of the NGQPENNYK peptide for 0, 1,3 and 7 days of stress at pH = 8.5

Furthermore, silk fibroin itself exhibits therapeutic effects, such as attenuating spatial learning and memory impairments and preventing neuronal damage in A 25 35 -induced rat models through the reduction of Tau hyperphosphorylation and suppression of neuroinflammation (Yao et al., 2022), and preventing A- and/or reactive oxygen species-induced inflammation and apoptosis, along with improved cognitive function by increasing acetylcholinesterase (De Giorgio et al., 2024)