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[DOI] [PubMed] [Google Scholar] 140.Durrieu MC, Pallu S, Guillemot F, Bareille R, Amedee J, Baquey CH, et al

It's the single biggest mistake we see labs make, and it invalidates every data point that follows

Given the growing therapeutic interest in TREM2-mediated modulation of microglial function, nanoparticle-based systems may also provide opportunities to enhance the brain delivery of TREM2-targeted biologics or nucleic acid therapeutics (Li et al., 2024

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This is the question most people are really asking and the honest answer is: they can be effective, but results are not universal and are heavily influenced by dosage, frequency, delivery method, and individual biology