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Maintenance: For maintenance, apply GHK-Cu cream once or twice weekly to the target area, for four to six months following the initial study

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The administering provider must be a physician, nurse practitioner, or physician assistant

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Given that these species can accumulate not only through increased production but also through decreased clearance, an inadequate antioxidant response, particularly associated with a dysregulation of NRF2 transcriptional activity, could explain their gradual accumulation