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Upon activation, HSF1 trimers translocate to the nucleus and bind to heat shock elements (HSEs) in the promoters of target genes, thereby increasing the transcription of HSP70s, which then undergo degradation or re-monomerization (Vihervaara and Sistonen, 2014)

However, nasal spray's rapid onset may benefit acute injuries, while oral administration might better support chronic gastrointestinal issues through direct tissue contact

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