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Ketter, J

Preclinical evidence Mice with a deletion of the 22q11.2 locus containing most proteins expressed in mitochondria [19] show increased cytoplasmic 8-oxo-2-deoxyguanosine (suggesting mitochondrial DNA oxidation), reduced number of PV-immunoreactive interneurons, and weakened PNN in anterior cingulate cortex [15]

Hormone Replacement Therapy (HRT) works by restoring hormones your body no longer produces at optimal levels
Complementation of mutant and wild-type human mitochondrial DNAs coexisting since the mutation event and lack of complementation of DNAs introduced separately into a cell within distinct organelles

PMID: 33255818

Takeda A, Hisada H, Okada S, Mata JE, Ebadi M, Iversen PL
