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Geiler J, Michaelis M, Naczk P, et al

29 HoqueT

If ROS are not eliminated, macromolecular structures, including membranes, proteins, and mitochondrial DNA, can be damaged
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Pulm Pharmacol Ther

Importantly, the intraosseous delivery of AAV-delivered Chac2 shRNA in db/db mice with periodontitis markedly reduced neutrophil-aggravated systemic inflammatory comorbidity symptoms and improved glycemic control, underscoring the functional relevance of this pathway in diabetic comorbidity
