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We can't stress this enough: for tissues with poor vascularity, like many ligaments and tendons, getting a therapeutic compound to the site is half the battle

However, there are interobserver variabilities, which must be taken into account

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What they did: n 536 adults with obesity (BMI 30 to 45)

Finally, the design of long-term trials with clinically meaningful endpoints encounters logistical challenges, as demonstrated by the premature termination of numerous phase III studies due to insufficient enrollment or delayed therapeutic effects