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10.1016/j.semcancer.2017.11.001 Semin Cancer Biol

On the other hand, AR inhibitors inhibit high glucose-induced ROS production and apoptosis in HUVECs, restore Sirtuin 1 (SIRT1) expression and phosphorylation of AMPK1, and reduce mTOR phosphorylation, preventing hyperglycaemia-induced endothelial cell death and dysfunction [50]

Preliminary experiments reveal that the choice of oxidant solution and the ratio between the concentration of DMPD + and the oxidative compound are critical for the methods effectiveness

This state known as oxidative stress

[4] Verywell Health

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