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Isatuximab interacts with a discontinuous epitope partially overlapping the catalytic site, whereas Daratumumab binds to two continuous amino acid sequences situated outside the enzymatic active site of CD38 (52, 53)
When CNGB3-expressing HEK293T cells were cultured in a medium containing z13 (100 g ml 1 ), dKLAK-z13 (100 g ml 1 ) or HLAH-z13 (25 g ml 1 ) at 37 C for 20 h, cells did not undergo apoptosis (Fig

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