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To address this point, it was explored whether APOE treatment of neurons affected the catalytic activity of enzymes that have previously been implicated in tau phosphorylation, such as glycogen synthase kinase 3beta (GSK3), P35, and cyclin-dependent protein kinase 5 (CDK5)

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When present in over abundant levels reducing sugars like glucose or fructose react non-enzymatically with free amino groups of proteins, lipids, or nucleic acids to initially form Schiff bases or Amadori adducts ( Figure 2 ) ( Figure 2 Protein kinase C pathway Diabetes induced elevation in circulating glucose levels leads to the accumulation of glucose in cells independent of insulin for glucose transport

(2014) 9:e103067

10.1016/j.bbabio.2016.03.006 104 ScaliseM.PochiniL.PanniS.PingitoreP.HedfalkK.IndiveriC