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The two approaches may be complementary rather than mutually exclusive

63 , e12422 (2017)

The intrinsic mitochondrial pathway is mediated by changes in the regulation of proapoptotic (Bax) and antiapoptotic (reduced expression of Bcl-2, Bcl-xL) proteins from the Bcl-2 family in various lung cancer cells (A549, H460) similar to other chalcones