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Unsaturated VPA metabolites (4-en-VPA and 2, 4-dien-VPA) are potent inducers of microvesicular steatosis in rats, whereas VPA itself failed to induce discernible liver lesions at near lethal doses [60]

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In the coming years, this in vivo model could be widely used to better characterize microorganisms using omics approaches associated with automation

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Therefore, there is a rising interest in deciphering the molecular mechanisms of HSF1 regulation, the interplay between the downstream signaling pathways and its broad role in proteostasis maintenance and thermotolerance