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Many mechanisms have been proposed to explain MDR, such as the decrease in intracellular drug concentrations due to efflux pump induction, the mutation of drug targets, the upregulated metabolic detoxification, and the enhanced DNA damage repair function [63]

To confirm that the improved response to cold was dependent on creatine, mice were treated with the creatine-depleting drug -guanidinopropionic acid (-GPA) 21 , which can only be used acutely as chronic exposure can induce weight loss 19,21

Todorova MT, Burwell TJ, Seyfried TN (1999) Environmental risk factors for multifactorial epilepsy in EL Mice

Maceyka et al., 2005), and based on the location of production, has distinct functions (Kumar et al., 2017)

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