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Park J.S., Mathison B.D., Hayek M.G., Zhang J., Reinhard G.A., Chew B.P

However, a larger increase in glutamate content without concomitant decrease in aspartate observed in an epileptic patient almost certainly represents increased de novo synthesis (Mangia et al., 2012)

Iron chelators, such as DFP, DFX, and DFO, have been shown to significantly reduce iron overload and serum iron levels in patients with thalassaemia [113,114,115]

Ruiz-Pozo et al., 2023) The PI3K/Akt pathway is also responsible for regulating protein clearance systems like autophagy and the ubiquitin-proteasome system

The occurrence of these complications suggests a potential role of immune checkpoint molecules in maintaining cardiovascular homeostasis, and disruption of physiological immune checkpoint signalling might thus lead to cardiac pathologies, including heart failure