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Senescent Endothelial Cell Elimination & Vascular Ageing (Frontiers in Bioengineering, 2025/2026) p53/BCL-2/Caspase-3 Pathway Activation Selectively Clears Senescent Endothelial Cells A study published in Frontiers in Bioengineering and Biotechnology investigated the mechanism by which FOXO4-DRI induces apoptosis in senescent endothelial cells

Hewitt, R

Asian Journal of Andrology

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[5], [6], [7] Transcription factors of the FOXO family specifically FOXO1, FOXO3, FOXO4, and FOXO6 are key mediators of insulin and IGF signaling, participating in the regulation of a wide range of cellular processes, including metabolism, cell growth and differentiation, response to oxidative stress, autophagy, senescence, and aging-related processes