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Finally, we also found the NO accumulating mutant nox1 to be highly sensitive to TMHT, as previously described at 45C (Lee et al., 2008) ( Figure 4C )

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In support of this, high levels of SRC3 along with HER2 overexpression are associated with worse outcomes following tamoxifen therapy, indicating roles for growth factor receptor signaling in tamoxifen-stimulated growth and resistance (Osborne et al ., 2003)