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Combination therapies with curcumin and compounds like salidroside, berberine, or glucose enhance therapeutic outcomes by inhibiting inflammatory responses, enhancing antioxidant capacity, alleviating liver injury, regulating the miR-221/SOX11 axis, activating pro-apoptotic proteins, and alkalizing the tumor microenvironment to inhibit HCC cell proliferation and migration

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doi: 10.3390/vaccines11111658 69 KaurJ.NobileC

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While both Lip-1 and Fer-1 operate through similar mechanisms, Lip-1 possesses better pharmacokinetic properties, allowing it to inhibit ferroptosis effectively at lower doses (Wang et al., 2022c)