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Importantly, when combined with curcumin, 3,4-DHPV exhibited a strong synergistic anti-inflammatory effect at low micromolar concentrations (5 M 3,4-DHPV + 5 M curcumin), markedly reducing the expression of multiple pro-inflammatory genes (e.g., IL-6, MCP-1, COX-2, IL-1, TNF-, iNOS) and their secreted protein levels (Marcolin et al., 2025)

Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis. J Physiol Paris 93(4):315321

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