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however, it is widely believed to be linked to aberrations in both sugar and fat metabolism

When activated, the complex leads to the cleavage of the proforms of the cytokines IL-1 and IL-18, which themselves become activated and secreted to further amplify inflammation and immune responses

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There is absolute chance of presence of undesirable particles or endotoxins in solution, so sterile filter is used in pharmaceutical industry to get rid of all of them