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At pathological level, ROS becomes highly reactive, causing substantial damage to various cellular biomolecules such as nucleic acids, proteins and lipids (41)

Upon re-testing, one hit, the crude product of 2 and a pyrrolidine spirosuccinimide building block ( 3 ), selectively decreased HiBiT-ENL signal without impacting BRD4-HiBiT (Fig

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d-e , Distances between the catalytic triad in R152H variant were measured and labeled as compared to GPX4 U46C (PDB:2OBI)